CUENCA, Patricia and RAMIREZ, Vanessa. Aberraciones cromosómicas en trabajadoras expuestas a plaguicidas. Rev. biol. trop [online]. , vol, n.3, pp. ABERRACIONES. CROMOSÓMICAS. Dra. Laura Santana Díaz Médico Genetista. Morfología y estructura de los cromosomas humanos. Cariotipo Constitución. PDF | On Jan 1, , Fernado N. Dulout and others published Análisis de aberraciones cromosómicas en anafase-telofase de la mitosis. I. Acción clastogénica.

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The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Zalacain 1L. The in vitro micronucleus technique. A protocol for the in vitro micronucleus test.

Al contrario, varias publicaciones han detectado diferencias entre grupos de fumadores y no fumadores: Micronucleus monitoring of a floriculturist population from western Liguria, Italy.

Effect of smoking habit on the frequency of micronuclei in human lymphocytes: Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences.

Micronucleus formation in peripheral-blood lymphocytes from smokers aberrackones the influence of alcohol- and tea-drinking habits. Influence of smoking habit on the frequency of micronuclei in human lymphocytes by the cytokinesis block method. The cytogenetic assay as a measure of genetic instability induced by genotoxic agents. What do human micronuclei contain?

Conferencia: Impacto de las Aberraciones Cromosómicas en la Salud. ~ Ciber-Genética

Micronuclei frequencies in hospital workers occupationally exposed to low levels of ionizing radiation: Fenech M, Crott JW. Micronuclei in cytokinesis-blocked lymphocytes as an index of occupational exposure to alkylating cytostatic drugs. Micronucleus induction in aberraclones cells of green-lipped mussels Perna viridis exposed to mixtures of polycyclic aromatic hydrocarbons and chlorinated pesticides. Measurement of micronuclei in lymphocytes.


Wberraciones position of the in vitro micronucleus test within the battery of screening for genotoxic potential determination and the regulatory guidelines. Kirsch-Volders M, Fenech M. Importance of detecting numerical versus structural chromosome aberrations.

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Chromosomal instability in amniocytes from fetuses of mothers who smoke. Factors contributing to chromosome damage in lymphocytes of cigarette smokers. Cytogenetic biomonitoring of Spanish greenhouse workers exposed to pesticides: Hainaut P, Pfeifer GP.

Fenech M, Morley AA. Micronuclei and chromatid buds are the result of related genotoxic events. El recuento de MN se debe realizar sobre 1. Cancer Res ; Jpn J Cancer Res ; Micronuclei in lymphocytes of young patients under antileukemic therapy.

Int J Cancer ; Mutat Res ; Cancer Lett ; Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay.

Ginseng reduces the micronuclei yield in lymphocytes after irradiation.

The micronuclei scoring is performed on binucleated cells and the starting sample may vary, although most studies are performed on peripheral blood lymphocytes. Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1, subjects in an Italian population: Environ Toxicol Chem ; The cytogenetic assay for the detection of micronuclei CBMN: Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei.

The micronucleus assay in human lymphocytes: Norppa H, Falck GC. Chem Res Toxicol ; Sex chromosome loss, micronuclei, sister chromatid exchange and aging: Environ Mol Mutagen ; The cytokinesis-block micronucleus technique: Mutability of p53 hotspot codons to benzo a pyrene diol epoxide BPDE and the frequency of p53 mutations in nontumorous human lung.


Evaluation of micronuclei frequency in the cultured peripheral blood lymphocytes of cancer patients before and after radiation treatment. Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants vitamin E, vitamin C, beta-carotene and red ginseng. The micronuclei assay is considered a practical, universally validated and technically feasible protocol which is useful to evaluate the genetic instability induced by genotoxic agents.

There are several factors able to modify the number of micronuclei present in a given cell, among them are age, gender, vitamins, medical treatments, daily exposure to genotoxic agents, etc.

High susceptibility to lung abfrraciones analyzed in terms of combined genotypes of PIA1 and Mu-class glutathione S-transferase genes.

Contribution of sex, age, and lifestyle. Cell division, chromosomal damage and micronucleus formation in peripheral lymphocytes of healthy donors: Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity.