Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.
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This is a site-specific and time-dependent formulation; i. Of particular concern are weak, basic drug compounds that are insoluble at a pH greater than five.
Diffucaps® Customized Release Technology | Adare Pharmaceuticals | CPhI Online
Electrically credible polymer gel yechnology controlled release of drugs. Schematic representation of different drug delivery systems where A sigmoidal release after lag time B delayed release after lag time C sustained release after lag time D extended release without lag time.
Eurand Minitabs combine the simplicity of tablet formulation with the sophistication of multiparticulate systems, suitable for high drug loading, and can be used as a sprinkle for pediatric and geriatric patients who have difficulty swallowing tablets.
Indian journal of Pharmaceutical sciences Capsule Shaped Pulsatile Drug Delivery System This dosage form consists of an insoluble capsule body containing drug and a release controlling plug Soluble is fitted between immediate release compartment and pulsed release compartment Figure. This system controls release rates for multiple ingredients within a single tablet in a programmed manner.
The length of the plug and its point of insertion into the capsule controlled the lag time. Single-file diffusion of protein drugs through cylindrical nanochannels. Time-controlled pulsatile release systems Delivery systems containing erodible coating layer Bulk-eroding system Bulk erosion means that the ingress of water is faster than the rate of degradation. Time controlled or site specific single or multiple units are obtained by pulsatile drug delivery techniques.
Timing drug availability with therapeutic need. To solve this problem OSDRC-technology one-step dry-coated tablet system, OSDRC-system was developed that employs a double-structure punch center punch and outer punch allowing for dry-coated tablets to be assembled in a single run.
OROS Technology Osmotic-controlled Release Oral delivery System This technology depends on osmotic pressure to give pre-programmed, controlled drug delivery to the gastrointestinal tract. In this system, drug is released when polymer undergoes swelling or deswelling phase in response to chemical reaction with membrane, alteration of pH and Inflammation induce3, 4, These gels shrink at a transition temperature that is referred to the lower critical solution temperature LCST of the linear polymer.
Evaluation of novel one-step dry-coated tablets as a platform for delayed-release tablets. Examples of the pH sensitive polymers include N, N- dimethylaminoethyl methacrylate, chitosan, polyol etc3, 7, 15, Thus, it is possible to treat patients with inflammatory diseases like rheumatoid arthritis; using anti inflammatory drug incorporated HA gels as new implantable drug delivery systems5, 7,10,11, These systems consist of an outer release controlling water insoluble but permeable coating subject to mechanically induced rupture phenomenon.
The same cannot be either achieved or the benefits are partial when it comes to conventional dosage forms. J of Advances in Pharmacy, Biology and Chemistry ;1: A number of research groups have investigated purposed formulation by using this system. The Time Clock system consists of a solid dosage form coated with lipid barriers containing carnauba wax and bees wax along with surfactants. In case of cardiovascular diseases, BP is at its lowest during the sleep cycle and rises steeply during the early morning period.
The beads oscillate within the matrix on exposure ciffucaps the magnetic field, alternatively creating compressive and tensile forces. When it comes in contact with aqueous fluids, the cap rapidly dissolves thereby releasing the immediate release component followed by pulsed release component.
The Geomatrix TM technology is applied to achieve customized levels of controlled release of specific difcucaps and can achieve simultaneous release of two different drugs and different rates from a single tablet.
Assessing the abuse potential of an oral osmotic-controlled extended release OROS hydromorphone compared to immediate release hydromorphone. Patel and Patel developed a modified Pulsincap device containing diclofenac sodium to target the drug in the colon.
Release properties, such as trchnology time and release rate, were manipulated by varying the printing parameters.
This device consists of a non-disintegrating half capsule body sealed at the open end with a hydrogel plug that is covered by a water-soluble cap.
European Journal of Pharmaceutical Sciences ; In addition, 3DP can also provide solutions for resolving difficulties relating to the delivery of poorly water-soluble drugs, peptides and proteins, highly toxic and potent drugs and controlled release of multidrugs in a single dosage forms.
Diffucaps® Customized Release Technology
Internally stimuli induced system 2. International Journal of Pharmaceutics ; Preparation of enteric coated timed-release press-coated tablets and evaluation of their function by in vitro and in vivo tests for colon targeting.
Electrically responsive delivery systems are prepared from polyelectrolytes and are thus technoolgy responsive as well as electroresponsive. Antigenantibody complex formation is of great importance as the cross-linking units in the gel due to such specific interaction.
Scherer International Corporation, Michigan developed the pulsincap system, in which the lag time is continued by a plug that gets pushed away by swelling or technolkgy, releasing the drug as a pulse from the insoluble capsule body.
Design and Evaluation diffucapd Enteric press coated tablet for pulsatile delivery of Atenolol ; 1 2: In the human body numerous kinds of technologh compounds are exist.
Under the influence of an electric field, electroresponsive hydrogels generally deswell, swell or erode. Lower dosages are expected upon dilution of the initial drug solution. It is reported that the weak and non-flexible ethyl cellulose film ruptured adequately as compared with more flexible viffucaps. This delay is introduced by the level of non-enteric release-controlling polymer applied to drug-loaded beads. A drug core granulated or layered onto a neutral surface is created, followed by the application of one or more rate-controlling, functional polymer membranes.
These systems consist of reservoir with either rupturable or altered permeability coating and most commonly housed in Capsular body. TMDS time multiple action delivery system This system controls release rates for multiple ingredients within a single tablet in a programmed manner. When both these systems come in contact with aqueous medium, the coat emulsifies or erodes after the lag time.
These rhythms allow organism to anticipate and prepare for precise and regular environment changes. As it undergo volume change, this property can be utilised to technopogy a squeezing hydro gel device by positioning hydro gel within a rigid capsule.
Recent technologies in pulsatile drug delivery systems
The development of stimuli-sensitive delivery systems has been the latest topic of interest. The beads contain a layer of organic acid or alkaline buffer to control the solubility of a techonlogy by creating an optimal pH microenvironment for drugs that exhibit poor solubility in intestinal pH, in environments with pH greater than 8.
Gastro retentive drug delivery system is a suggestion to prolong gastric residence time, thereby targeting site-specific drug release in upper gastrointestinal GI tract.